Major CORTEX Project Inches Forward

UPDATE: The construction appears to be for the nearby Neuroscience building under construction just down the block. Although the construction is on the site of the 4210 site, this may not yet be an indication of the project being restarted. The story will be updated as more information unfolds.

St. Louis is on the precipice of becoming a major city for fostering startups, seeing massive venture capital growth over the last several years and now regularly finding itself topping coveted lists. One recent study from JobSage found that St. Louis was the top city in the nation for successful minority-owned businesses, finding that 25% of STL startups were minority-owned with average annual sales totaling almost $200,000.

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The St. Louis Business Journals also reported that St. Louis saw a regional record-setting amount of investment dollars, totaling almost $250,000,000 in 2021 alone. The amount of investment has swelled in recent years as the city finds itself in the top 30 markets for investment from Bay Area and New York based firms, having attracted only around $30-$40,000,000 annually between 2010 and 2013. That growth is remarkable and palpable for St. Louis area businesses and can likely be attributed to the major investments in infrastructure and networks within the Cortex Innovation Community.

CORTEX – Source: Cortex Innovation Community

If you’re unfamiliar with the Cortex, it’s an innovation community sandwiched between Forest Park Southeast, the Central West End, and Midtown. It’s several acres of high tech office space, innovation hubs, restaurants, research labs, a hotel, and soon to be residential space once KDG’s Cortex K project gets off the ground. Over the past decade, it has seen several new buildings rise and has attracted businesses including Boeing, Microsoft, and labs from WUSTL and BJC.

One office in particular, to be located at 4210 Duncan, has been an object of interest in the local urbanism community for some time. The development has been stalled since late 2020, perhaps due to leasing issues rooted in the effects of the pandemic. This building would total over $100 million dollars in investment and has a fascinating design and would have a huge presence in the community should it actually get built. With 8 and a half levels of office space, labs, and retail, it would fill out the Eastern edge of the district with a sizable presence and the façade is unlike anything we’ve seen before in the St. Louis market.

Without a whisper, it seems as though the developer has finally restarted their efforts. Over the last couple of days, the construction gates have been open as workers returned to some incomplete foundation work. Some witnessed cement trucks entering the gates and workers seemingly restarting construction. What we haven’t seen yet are the building permits, so time will tell if this is only a temporary measure, or really the start to one of the most architecturally interesting office buildings in STL getting underway.

New Hotel Planned in Midtown

Even as St. Louis has experienced record levels of development over the last few years, Midtown still tends to lag other neighborhood, particularly near the Wells Fargo Campus. That’s all set to change with the Jefferson Connector, part of the Midtown Alley project.

The Midtown Alley project is set to include more residential units with the Beaumont Lofts, office space, and of course the new hotel project dubbed the Jefferson Connector. The hotel portion will renovate a large section of the Wells Fargo campus, as pictured below.

This stretch of Jefferson will benefit from significantly more activity and should make the Western edge of Downtown far more welcoming to visitors. The hotel will boast just over 200 rooms and should be completed sometime in 2023, according to the developers at Green Street.


With the new MLS Stadium, a rehabilitated Union Station, and this new hotel, Midtown should look and feel very different in just a few years time.

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